NationStates Jolt Archive

Welcome to Louisiana Strategic Works (LSW)

Welcome to Louisiana Strategic Works. LSW specializes in the manufacturing and selling of nuclear, biological, and chemical weapons and their operating systems to responsible nations. Before you consider purchasing from LSW, do you pass the following qualifications?

1.) Is your population atleast 100 million? (Only necessary for Nuclear Purchases)
2.) Is your nation responsible enough to own nuclear, chemical, or biological weapons?
3.) Does your nation have enough funds not only to pruchase, but to maintain these units?

If you have answered yes to the 3 qualifications, then you are ready to purchase. (I ask all nations to please check your budgets before you purchase at: http://nseconomy.thirdgeek.com/)

LSW has reserved the right not to sell to any nation we see fit. LSW nor Communist Louisiana can not be held accountable once these nuclear weapons are out of our nations hands.

PLEASE DO YOUR OWN MATH OR WE WILL CHARGE DOUBLE AS A BANKING FEE

Didnt you already had a storefront? And what can we buy?

Intercontinental Ballistic Missiles(ICBM)

LGM-30 Minuteman III
http://www.globalsecurity.org/wmd/systems/images/lgm-30-dvic441.jpg

Power Plant: Three solid propellant rocket motors;
First stage, Thiokol;
Second stage, Aerojet-General;
Third stage, United Technologies Chemical Systems Division

Thrust: First stage, 202,600 pounds (91,170 kilograms)

Length: 59.9 feet (18 meters)

Weight: 79,432 pounds (32,158 kilograms)

Diameter: 5.5 feet (1.67 meters)

Range: 6,000-plus miles (5,218 nautical miles)

Speed: Approximately 15,000 mph (Mach 23 or 24,000 kph) at burnout

Ceiling: 700 miles (1,120 kilometers)

Guidance Systems: Inertial system: Autonetics Division of LSW;
ground electronic/security system: Sylvania Electronics Systems and LSW.

Warheads: Three

Unit Cost: $20 million


LGM-118A Peacekeeper
http://www.globalsecurity.org/wmd/systems/images/pk-picc.jpg

Power Plant: First three stages, solid-propellant; fourth stage, storable liquid (by Aerojet)

Length: 71 feet (21.8 meters)

Weight: 195,000 pounds (87,750 kilograms) including re-entry vehicles

Diameter: 7 feet, 8 inches (2.3 meters)

Range; Greater than 6,000 miles (5,217 nautical miles)

Speed: Approximately 15,000 miles per hour at burnout (Mach 20 at sea level)

Guidance Systems: Inertial system: Autonetics Division of LSW;
ground electronic/security system: Sylvania Electronics Systems and LSW.

Warheads: Ten

Unit Cost: $70 million


SS-8
http://www.videocosmos.com/images/calendar/16031962.jpg

Propulsion: 2-stage liquid

Length: 24.19 m

Launch Weight: 80,000 kg

Diameter: 2.68 m

Range: 10,300 km, 16,000 km

Warhead: Nuclear, 1.65-3 MT or 5 MT

Payload: Single warhead, 1,650 to 2,100 kg

Basing: Silo based

Unit Cost: $80 million


Atlas D
http://images.google.com/images?q=tbn:uvtgEPHbCBkJ:www76.pair.com/tjohnson/ma2s.jpg

Propulsion: 2-stage liquid

Length: 23.11 m

Launch Weight: 120,200 kg

Diameter: 3.05 m

Range: 14,000 km

Warhead: Nuclear W49 1.44 MT

Payload: Single Mk 3/4 RV

Basing: Surface based

Unit Cost: $90 million

Submarine Launched Ballistic Missiles(SLBM)

Trident I C-4 FBM
http://www.globalsecurity.org/wmd/systems/images/slbm-dvic422-s.jpg

Power Plant: Three-stage solid-propellant rocket (by Aerojet)

Length: 34ft (10.2m)

Weight: 73,000lbs (32,850kg)

Diameter: 6ft 2in (1.9m)

Range: 4,350nm (5,000mi; 8,050km)

Max. Altitude: Sub-orbital

Guidance Systems: Inertial system: Autonetics Division of LSW

Warheads: Eight

Unit Cost: $20 million


Trident II D-5 Fleet Ballistic Missile
http://www.globalsecurity.org/wmd/systems/images/d5_06.jpg

Power Plant: Three-stage solid-propellant rocket
1st and 2nd stage burn times are 65 seconds each
3rd stage burn time is 40 seconds

Length: 44 feet (13.41 meters)

Weight: 130,000 pounds (58,500 kg)

Diameter: 74 inches (1.85 meters)

Range: 6,000nm (6,900mi; 11,000km)
Greater than 4,000 nautical miles (4,600 statute miles, or 7,360 km)

Max. Altitude: Sub-orbital

Guidance Systems: Inertial system: Autonetics Division of LSW

Warheads: 8 W88 300-475 kiloton MIRVs in a solid-fuel Mk 5 PBV

Unit Cost: $35 million

Chemical Weapons

Amounts are sold in 100 lbs airtight bags placed in airtight metal barrels

Soman (GD) Nerve Agent
runny nose, tightness of the chest and breathing difficulty,eye pain, dimness of vision and pin pointing of pupils (miosis), difficulty in breathing and cough, increased eye symptoms with blurred vision, drooling and excessive sweating, severe nasal congestion, increased tightness of the chest and breathing difficulty, nausea, vomiting, diarrhea, and cramps, generalized weakness, twitching of large muscle groups, headache, confusion, and drowsiness, involuntary defecation and urination, very copious secretions, twitching, jerking, staggering and convulsions, cessation of breathing, loss of consciousness, coma and death.

Price: 10,000


Phosgene (CG) Pulmonary/Choking Agent
During or immediately after exposure to dangerous concentrations of phosgene, the following signs and symptoms may develop: Coughing, Burning sensation in the throat and eyes, Watery eyes, Blurred vision, Difficulty breathing or shortness of breath, Nausea and vomiting, Skin contact can result in lesions similar to those from frostbite or burns, Following exposure to high concentrations of phosgene, a person may develop fluid in the lungs (pulmonary edema) within 2 to 6 hours. Exposure to phosgene may cause delayed effects that may not be apparent for up to 48 hours after exposure, even if the person feels better or appears well following removal from exposure. Therefore, people who have been exposed to phosgene should be monitored for 48 hours afterward. Delayed effects that can appear for up to 48 hours include the following: Difficulty breathing, coughing up white to pink-tinged fluid (a sign of pulmonary edema), Low blood pressure, Heart failure

Price: 10,000


Nitrogen Mustard (HN-2) Blister Agent
Redness of skin, blistering, eyes can burns and blindness may occur, nose and sinus pain, cough, sore throat, and shortness of breath may occur within hours, abdominal pain, diarrhea, nausea, and vomiting, brain is prone to tremors, in coordination, and seizures are possible following a large exposure.

Price: 10,000


Mustard/Lewisite (HL) Blister Agent (Mixture)
Skin: pain and irritation within seconds to minutes, redness within 15 to 30 minutes followed by blister formation within several hours. The blister begins as a small blister in the middle of the red areas and then expands to cover the entire reddened area of skin. The lesions (sores) from lewisite heal much faster than lesions caused by the other blistering agents, sulfur mustard and nitrogen mustards, and the discoloring of the skin that occurs later is much less noticeable. Eyes: irritation, pain, swelling, and tearing may occur on contact. Respiratory tract: runny nose, sneezing, hoarseness, bloody nose, sinus pain, shortness of breath, and cough Digestive tract: diarrhea, nausea, and vomiting. Cardiovascular: “Lewisite shock” or low blood pressure may occur. Extensive breathing in of the vapors may cause chronic respiratory disease

Price: 10,000


Lewisite (L) Blister Agent
Signs and symptoms occur immediately following a lewisite exposure. Lewisite can have the following effects on specific parts of the body: Skin: pain and irritation within seconds to minutes, redness within 15 to 30 minutes followed by blister formation within several hours. The blister begins as a small blister in the middle of the red areas and then expands to cover the entire reddened area of skin. The lesions (sores) from lewisite heal much faster than lesions caused by the other blistering agents, sulfur mustard and nitrogen mustards, and the discoloring of the skin that occurs later is much less noticeable. Eyes: irritation, pain, swelling, and tearing may occur on contact. Respiratory tract: runny nose, sneezing, hoarseness, bloody nose, sinus pain, shortness of breath, and cough. Digestive tract: diarrhea, nausea, and vomiting. Cardiovascular: “Lewisite shock” or low blood pressure may occur

Price: 10,000


Hydrogen Cyanide (AC) Blood Agent
People exposed to a small amount of cyanide by breathing it are prone to, Rapid breathing, Restlessness, Dizziness, Weakness, Headache, Nausea and vomiting, Rapid heart rate. Exposure to a large amount of cyanide by any route may cause Convulsions. Low blood pressure, Slow heart rate, Loss of consciousness, Lung injury, Respiratory failure leading to death

Price: 10,000


Tabun (GA) Nerve Agent
People exposed to a low or moderate dose of tabun by inhalation, ingestion (swallowing), or skin absorption may experience some or all of the following symptoms within seconds to hours of exposure: Runny nose, Watery eyes, Small, pinpoint pupils, Eye pain, Blurred vision, Drooling and excessive sweating, Cough, Chest tightness, Rapid breathing, Diarrhea, Increased urination, Confusion, Drowsiness, Weakness, Headache, Nausea, vomiting, and/or abdominal pain, Slow or fast heart rate, Abnormally low or high blood pressure. Exposure to a large dose of tabun by any route may result in these additional health effects: Loss of consciousness, Convulsions, Paralysis, Respiratory failure possibly leading to death

Price: 10,000


GB-Nerve/Sarin Gas
Effects may occur within minutes or hours, depending upon the dose. They include: miosis (constriction of pupils) and visual effects, headaches and pressure sensation, runny nose and nasal congestion, salivation, tightness in the chest, nausea, vomiting, giddiness, anxiety, difficulty in thinking, difficulty sleeping, nightmares, muscle twitches, tremors, weakness, abdominal cramps, diarrhea, involuntary urination and defecation, with severe exposure symptoms progressing to convulsions and respiratory failure.

Price: 10,000


VX Nerve Agent
VX gas disrupts the transmission of communications between nerve cells. Symptoms of exposure to vx gas include increased heart rate and salivation, nausea, and vomiting. A fatal dose of vx nerve gas causes convulsions, respiratory paralysis, and death within several minutes.

Price: 13,000

Biological Weapons

Amounts are sold in 500 lbs airtight bags placed in airtight metal barrels

Anthrax
Anthrax is a zoonotic disease caused by Bacillus anthracis. There are two types of this disease: cutaneous anthrax and inhalation anthrax. About 95% of the human anthrax cases in the United States have been in the former category. Cutaneous anthrax develops when a bacterial organism from infected animal tissues becomes deposited under the skin. When a patient contracts cutaneous anthrax, he develops a small elevated lesion on his skin which becomes a skin ulcer, frequently surrounded by sw elling or edema. The lymph gland near the lesion may also swell from the infection. If the lesion occurs on the neck or on or about the eye, it may cause complications. The incubation period for cutaneous anthrax is from one to seven days. When a patient does not receive an effective antibiotic, the mortality rate for cutaneous anthrax is 10-20%. With treatment, the mortality rate falls to less than 1%.

Inhalation anthrax develops when the bacterial organism is inhaled into the lungs. A progressive infection follows. Since inhalation anthrax is usually not diagnosed in time for treatment, the mortality rate in the United States is 90-100%. A b iological warfare attack with anthrax spores delivered by aerosol would cause inhalation anthrax, an extraordinarily rare form of the naturally occurring disease.

A lethal dose of anthrax is considered to be 10,000 spores; 80 percent of a population that inhaled such a dose would die. Less than one millionth of a gram is invariably fatal within five days to a week after exposure. According to an estimate by the US Congress's Office of Technology Assessment, 100 kilograms of anthrax, released from a low-flying aircraft over a large city on a clear, calm night, could kill one to three million people.

The disease begins after an incubation period varying from 1-6 days, presumably dependent upon the dose of inhaled organisms. Onset is gradual and nonspecific, with fever, malaise, and fatigue, sometimes in association with a nonproductive cough and m ild chest discomfort. In some cases, there may be a short period of improvement. The initial symptoms are followed in 2-3 days by the abrupt development of severe respiratory distress with dyspnea, diaphoresis, strider, and cyanosis. Physical findings may include evidence of pleural effusions, edema of the chest wall, and meningitis. Chest x-ray reveals a dramatically widened mediastinum, often with pleural effusions, but typically without infiltrates. Shock and death usually follow within 24-36 hours of respiratory distress onset.

An epidemic of inhalation anthrax in its early stage with nonspecific symptoms could be confused with a wide variety of viral, bacterial, and fungal infections. Progression over 2-3 days with the sudden development of severe respiratory distress follo wed by shock and death in 24-36 hours in essentially all untreated cases eliminates diagnoses other than inhalation anthrax. The presence of a widened mediastinum on chest x-ray, in particular, should alert one to the diagnosis. Other suggestive findings include chest-wall edema, hemorrhagic pleural effusions, and hemorrhagic meningitis. Other diagnoses to consider include aerosol exposure to SEB; but in this case onset would be more rapid after exposure (if known), and no prodrome would be evident prior to onset of severe respiratory symptoms. Mediastinal widening on chest x-ray will also be absent. Patients with plague or tularemia pneumonia will have pulmonary infiltrates and clinical signs of pneumonia (usually absent in anthrax).

Almost all cases of inhalation anthrax in which treatment was begun after patients were symptomatic have been fatal, regardless of treatment. Historically, penicillin has been regarded as the treatment of choice, with 2 million units given intravenousl y every 2 hours. Tetracycline and erythromycin have been recommended in penicillin-sensitive patients. The vast majority of anthrax strains are sensitive in vitro to penicillin. However, penicillin-resistant strains exist naturally, and one has been recov ered from a fatal human case. Moreover, it is not difficult to induce resistance to penicillin, tetracycline, erythromycin, and many other antibiotics through laboratory manipulation of organisms. All naturally occurring strains tested to date have been s ensitive to erythromycin, chloramphenicol, gentamicin, and ciprofloxacin.

Vaccines are available against some forms of anthrax, but their efficacy against abnormally high concentrations of the bacteria is uncertain. A licensed, alum-precipitated preparation of purified B.anthracis protective antigen (PA) has been shown to be effective in preventing or significantly reducing the incidence of inhalation anthrax. Limited human data suggest that after completion of the first three doses of the recommended six-dose primary series (0, 2, 4 weeks, then 6, 12, 18 months), protection against both cutaneous and inhalation anthrax is afforded. As with all vaccines, the degree of protection depends upon the magnitude of the challenge dose; vaccine-induced protection is undoubtedly overwhelmed by extremely high spore challenge.

If there is information indicating that a biological weapon attack is imminent, prophylaxis with ciprofloxacin (500 mg po bid), or doxycycline (100 mg po bid) is recommended. If unvaccinated, a single 0.5 ml dose of vaccine should also be given subcut aneously. Should the attack be confirmed as anthrax, antibiotics should be continued for at least 4 weeks in all exposed.
PRICE: $250,000

Botulinum Toxins
Botulism is caused by intoxication with the any of the seven distinct neurotoxins produced by the bacillus, Clostridium botulinum. The toxins are proteins with molecular weights of approximately 150,000, which bind to the presynaptic membrane of neurons at peripheral cholinergic synapses to prevent release of acetylcholine and block neurotransmission. The blockade is most evident clinically in the cholinergic autonomic nervous system and at the neuromuscular junction. A biological warfare attack with botulinum toxin delivered by aerosol would be expected to cause symptoms similar in most respects to those observed with food-borne botulism.

In pure form, the toxin is a white crystalline substance, that is readily dissolvable in water, but decays rapidly in the open air. Symptoms of inhalation botulism may begin as early as 24-36 hours following exposure or as late as several days. Initia l signs and symptoms include ptosis, generalized weakness, lassitude, and dizziness. Diminished salivation with extreme dryness of the mouth and throat may cause complaints of a sore throat. Urinary retention or ileus may also occur. Motor symptoms usuall y are present early in the disease; cranial nerves are affected first with blurred vision, diplopia, ptosis, and photophobia. Development of respiratory failure may be abrupt. Mucous membranes of the mouth may be dry and crusted. Neurological examination shows flaccid muscle weakness of the palate, tongue, larynx, respiratory muscles, and extremities. Deep tendon reflexes vary from intact to absent.

The occurrence of an epidemic with large numbers of afebrile patients with progressive ocular, pharyngeal, respiratory, and muscular weakness and paralysis hints strongly at the diagnosis. Single cases may be confused with various neuromuscular disord ers such as atypical Guillain-Barrè syndrome, myasthenia gravis, or tick paralysis. The edrophonium (tensilon) test may be transiently positive in botulism.

Respiratory failure secondary to paralysis of respiratory muscles is the most serious complication and, generally, the cause of death. Reported cases of botulism prior to 1950 had a mortality of 60%. With tracheotomy and ventilator assistance, fat alities should be <5%. Intensive and prolonged nursing care may be required for recovery (which may take several weeks or even months).

A pentavalent toxoid of Clostridium botulinum types A, B, C, D, and E is available under IND status. This product has been administered to several thousand volunteers and occupationally at-risk workers and induces serum antitoxin levels that co rrespond to protective levels in experimental animal systems. The currently recommended schedule (0, 2, and 12 weeks, then a 1 year booster) induces solidly protective antitoxin levels in greater than 90 percent of those vaccinated after 1 year.
PRICE: $100,000

Brucellosis
Brucellosis is a systemic zoonotic disease caused by one of four species of bacteria: Brucella melitensis, B. abortus, B. suis, and B. canis; virulence for humans decreases somewhat in the order given. These bacteria are small gram-negative, ae robic, non-motile coccobacilli that grow within monocytes and macrophages. They reside quiescently in tissue and bone-marrow, and are extremely difficult to eradicate even with antibiotic therapy. Their natural reservoir is domestic animals, such as goats , sheep, and camels (B. melitensis); cattle (B. abortus); and pigs (B. suis). Brucella canis is primarily a pathogen of dogs, and only occasionally causes disease in humans. Humans are infected when they inhale contaminated aer osols, ingest raw (unpasteurized) infected milk or meat, or have abraded skin or conjunctival surfaces that come in contact with the bacteria. Laboratory infections are quite common, but there appears to be no human-to-human transmission; isolation of inf ected patients is, therefore, not required. Brucella species long have been considered potential candidates for use in biological warfare. The organisms are readily lyophilized, perhaps enhancing their infectivity. Under selected environmental cond itions (for example, darkness, cool temperatures, high C02), persistence for up to 2 years has been documented. When used as a biological warfare agent, Brucellae would most likely be delivered by the aerosol route; the resulting infecti on would be expected to mimic natural disease.

Brucellosis presents after an incubation period normally ranging from 3-4 weeks, but may be as short as 1 week or as long as several months. Clinical disease presents typically as an acute, non-specific febrile illness with chills, sweats, headache, f atigue, myalgias, arthralgias, and anorexia. Cough occurs in 15-25%, but the chest x-ray usually is normal. Complications include sacroiliitis, arthritis, vertebral osteomyelitis, epididymo-orchitis, and rarely endocarditis. Physical findings include Iymphadenopathy in 10-20% and splenomegaly in 20-30% of cases. Untreated disease can persist for months to years, often with relapses and remissions. Disability may be pronounced. Lethality may approach 6% following infection with B. me litensis, but the disease is rarely fatal (0.5% or less) after infection with other serotypes (usually after endocarditis develops).

The initial symptoms of brucellosis are usually nonspecific, and the differential diagnosis is therefore very broad and includes bacterial, viral, and mycoplasmal infections. The systemic symptoms of viral and mycoplasmal illnesses, however, are usuall y present for only a few days, while they persist for prolonged periods in brucellosis. Brucellosis may be indistinguishable clinically from the typhoidal form of tularemia or from typhoid fever itself. The disease in humans is characterized by a multitud e of somatic complaints, including fever, sweats, anorexia, fatigue, malaise, weight loss, and depression. Localized complications may involve the cardiovascular, gastrointestinal, genitourinary, hepatobiliary, osteoarticular, pulmonary and nervous system s. Without adequate and prompt antibiotic treatment, some patients develop a ‘chronic’ brucellosis syndrome with many features of the ‘chronic fatigue’ syndrome.

The recommended treatment is doxycycline (200 mg/day) plus rifampin (900 mg/day) for 6 weeks. Alternative effective treatment consists of doxycycline (200 mg/day) for 6 weeks plus streptomycin (1 gm/day) for 3 weeks. Trimethoprimsulfamethoxazole given for 4-6 weeks is less effective. In 5-10% of cases, there may be relapse or treatment failure. Laboratory infections with brucellosis are quite common, but there is no human-to-human transmission and isolation is not required.

Killed and live attenuated human vaccines have been available in many countries but are of unproven efficacy. There is no information on the use of antibiotics for prophylaxis against human brucellosis.
PRICE: $100,000

Cholera
Cholera is a diarrheal disease caused by Vibrio cholera, a short, curved, gram-negative bacillus. Humans acquire the disease by consuming water or food contaminated with the organism. The organism multiplies in the small intestine and secretes an enterotoxin that causes a secretory diarrhea. When employed as a BW agent, cholera will most likely be used to contaminate water supplies. It is unlikely to be used in aerosol form. Without treatment, death may result from severe dehydration, hypovole mia and shock. Vomiting is often present early in the illness and may complicate oral replacement of fluid losses. There is little or no fever or abdominal pain.

Watery diarrhea can also be caused by enterotoxigenic E. coli, rotavirus or other viruses, noncholera vibrios, or food poisoning due to ingestion of preformed toxins such as those of Clostridium perfringens, Bacillus cereus, or Staphylococcus aureus.

Treatment of cholera depends primarily on replacement of fluid and electrolyte losses. This is best accomplished using oral dehydration therapy with the World Health Organization solution (3.5 g NaCL, 2.5 g NaHC03, 1.5 g KC1 and 20 g glucose per liter) . Intravenous fluid replacement is occasionally needed when vomiting is severe, when the volume of stool output exceeds 7 liters/day, or when severe dehydration with shock has developed. Antibiotics will shorten the duration of diarrhea and thereby reduce fluid losses.

Improved oral cholera vaccines are presently being tested. Vaccination with the currently available killed suspension of V. cholera provides about 50% protection that lasts for no more than 6 months. The initial dose is two injections given at least 1 week apart with booster doses every 6 months.
PRICE: $250,000

Clostridium Perfringens Toxins
Clostridium perfringens is a common anaerobic bacterium associated with three distinct disease syndromes; gas gangrene or clostridial myonecrosis; enteritis necroticans (pig-bel); and clostridium food poisoning. Each of these syndromes has very specific requirements for delivering inocula of C. perfringens to specific sites to induce disease, and it is difficult to imagine a general scenario in which the spores or vegetative organisms could be used as a biological warfare agent. There are , however, at least 12 protein toxins elaborated, and one or more of these could be produced, concentrated, and used as a weapon. Waterborne disease is conceivable, but unlikely. The alpha toxin would be lethal by aerosol. This is a well characterized, hi ghly toxic phospholipase C. Other toxins from the organism might be co-weaponized and enhance effectiveness. For example, the epsilon toxin is neurotoxic in laboratory animals.

Gas gangrene is a well-recognized, life-threatening emergency. Symptoms of the disease may be subtle before fulminant toxemia develops, and the diagnosis is often made at postmortem examination. The bacteria produce toxins that create the high mortali ty from clostridial myonecrosis, and which produce the characteristic intense pain out of proportion to the wound. Within hours signs of systemic toxicity appear, including confusion, tachycardia, and sweating. Most Clostridia species produce lar ge amounts of CO2 and hydrogen that cause intense swelling, hence the term "gas" gangrene, resulting in gas in the soft tissues and the emission of foul-smelling gas from the wound. Clinical features include necrosis, dark red serous fluid, and numerous g as filled vesicles. The infection may progress upto 10 cm per hour, and early diagnosis and therapy are essential to prevent rapid progression to toxemia and death. Pulmonary findings might lead to confusion with staphylococcal enterotoxin B (SEB) initia lly. Liver damage, hemolytic anemia, and thrombocytopenia are not associated with SEB and the pulmonary findings should be reversible in SEB.

No specific treatment is available for C. pefringens intoxication. Early antibiotic treatment is effective, if undertaken before significant amounts of toxins have accumulated in the body. If not treated the bacteria enter the bloodstream caus ing fatal systemic illness. The organism itself is sensitive to penicillin, and consequently, this is the current drug of choice. Recent data indicate that clindamycin or rifampin may suppress toxin production and provide superior results in animal models . Prompt surgical debridement and broad spectrum, intravenous antibiotics are the mainstay of therapy. Hyperbaric oxygen has not been proven effective in prolonging survival.

There is no available prophylaxis against most C. perfringens toxins. Toxoids are being used to prevent enteritis necroticans in humans, and veterinary toxoids are in wide use.
PRICE: $150,000

Congo-Crimean Hemorrhagic Fever
Congo-Crimean hemorrhagic fever (CCHF) is a viral disease caused by CCHF virus. The virus, first isolated in the Congo, is transmitted by ticks, principally of the genus Hyalomma, with intermediate vertebrate hosts varying with the tick species. The disease, next found in the Crimea, occurs also in the Middle East, the Balkans, the former USSR, and eastern China. In 1969 it was recognised that the pathogen causing Crimean haemorrhagic fever was the same as that responsible for an illness identified in 195 6 in the Congo, and linkage of the 2 place-names resulted in the current name for the disease and the virus. Little is known about variations in the virus properties over the huge geographic area involved. Humans become infected through tick bites, crush ing an infected tick, or at the slaughter of viremic livestock. Even in epidemics, cases do not show narrow clustering and person-to-person spread is rare. CCHF would probably be delivered by aerosol if used as a BW agent.

The length of the incubation period for illness appears to depend on the mode of acquisition of the virus. Following infection via tick bite, the incubation period is usually one to three days, with a maximum of nine days. The incubation period followi ng contact with infected blood or tissues is usually five to six days, with a documented maximum of 13 days. Typical cases present with sudden onset of fever and chills 3-12 days after tick exposure. There is severe headache, lumbar pain, nausea and vomi ting, delirium, and prostration. Fatal cases are associated with extensive hemorrhage, coma, and shock. Mortality among cases recognized as hemorrhagic fever is 15-30%, with death occurring in the second week of illness. In those patients who recove r, improvement generally begins on the ninth or tenth day after onset of illness. Convalescence in survivors is prolonged with asthenia, dizziness, and often hair loss.

Diagnosis of suspected CCHF is performed in specially-equipped, high biosafety level laboratories. Other viral hemorrhagic fevers, meningococcemia, rickettsial diseases, and similar conditions may resemble full-blown CCHF. Most fatal cases and half the others will have detectable antigen by rapid enzyme-linked immunosorbant assay (ELISA) testing of acute serum samples. IgM ELISA antibodies occur early in recovery.

Supportive therapy with replacement of clotting factors is indicated. Crimean-Congo hemorrhagic fever virus is sensitive to ribavirin in vitro and clinicians have been favorably impressed in uncontrolled trials. Immune globulin has also been re commended but is available only in Bulgaria.

When patients with CCHF are admitted to the hospital, there is a risk of nosocomial spread of infection. In the past, serious outbreaks have occurred in this way and it is imperative that adequate infection control measures be observed to prevent this disastrous outcome. Patients with suspected or confirmed CCHF should be isolated and cared for using barrier nursing techniques. Because of several well-defined outbreaks within hospitals, protective measures for medical personnel are an issue. The weigh t of evidence points to large droplets or fomites as the mediators of transmission and so strict barrier nursing is indicated and probably sufficient for the care of naturally acquired disease. The virus is aerosol-infectious and additional precautions (f or example, respirators) might be considered in a biological warfare setting.

Although there is little field experience and no definitive data on efficacy, the sensitivity of the virus to ribavirin and the severity of disease suggests that prophylaxis of high-risk exposures is indicated. In the case of a suspected biological att ack, ribavirin could be considered for prophylaxis, but there is insufficient information to make a firm recommendation for dosing. An inactivated mouse-brain vaccine is used in Bulgaria, but there is no general experience with this product.
PRICE: $150,000

Ebola Haemorrhagic Fever
Ebola Haemorrhagic Fever is one of the most virulent viral disease known to humankind, causing death in 50-90% of all clinically-ill cases. Consequently, it has figured prominently in popular discussions of biological warfare, although its practical appli cations as an biological warfare agent remain speculative. The disease has its origins in the jungles of Africa and Asia and several different forms of Ebola virus have been identified and may be associated with other clinical expressions, on which furthe r research is required.

The Ebola virus is transmitted by direct contact with the blood, secretions, organs or semen of infected persons. Transmission through semen may occur up to 7 weeks after clinical recovery, as with Marburg haemorrhagic fever. Health care workers have f requently been infected while attending patients. In the 1976 epidemic in Zaire, every Ebola case caused by contaminated syringes and needles died.

After an incubation period of 2 to 21 days, Ebola is often characterised by the sudden onset of fever, weakness, muscle pain, headache and sore throat. This is followed by vomiting, diarrhoea, rash, limited kidney and liver functions, and both internal and external bleeding. Specialized laboratory tests on blood specimens (which are not commercially available) detect specific antigens or antibodies and/or isolate the virus. These tests present an extreme biohazard and are only conducted under maximum c ontainment conditions.

No specific treatment or vaccine exists for Ebola haemorrhagic fever. Severe cases require intensive supportive care, as patients are frequently dehydrated and in need of intravenous fluids. Experimental studies involving the use of hyperimmune sera on animals demonstrated no long-term protection against the disease after interruption of therapy.

Suspected cases should be isolated from other patients and strict barrier nursing techniques practised. All hospital personnel should be briefed on the nature of the disease and its routes of transmission. Particular emphasis should be placed on ensuri ng that high-risk procedures such as the placing of intravenous lines and the handling of blood, secretions, catheters and suction devices are done under barrier nursing conditions. Hospital staff should have individual gowns, gloves and masks. Gloves and masks must not be reused unless disinfected. Patients who die from the disease should be promptly buried or cremated.

As the primary mode of person-to-person transmission is contact with contaminated blood, secretion or body fluids, any person who has had close physical contact with patients should be kept under strict surveillance, i.e. body temperature checks twice a day, with immediate hospitalization and strict isolation recommended in case of temperatures above 38.3 C (101 F). Casual contacts should be placed on alert and asked to report any fever. Surveillance of suspected cases should continue for three weeks a fter the date of their last contact. Hospital personnel who come into close contact with patients or contaminated materials without barrier nursing attire must be considered exposed and put under close supervised surveillance.

Different hypotheses have been developed to try to uncover the cycle of Ebola. Initially, rodents were suspected, as is the case with Lassa Fever whose reservoir is a wild rodent (Mastomys). Another hypothesis is that a plant virus may have caused the infection of vertebrates. Laboratory observation has shown that bats experimentally infected with Ebola do not die and this has raised speculation that these mammals may play a role in maintaining the virus in the tropical forest.
PRICE: $275,000

Melioidosis
Melioidosis is an infectious disease of humans and animals caused by Pseudomonas pseudomallei, a gram-negative bacillus. It is especially prevalent in Southeast Asia but has been described from many countries around the world. The disease has a variable and inconstant clinical spectrum. A biological warfare attack with this organism would most likely be by the aerosol route.

Infection by inoculation results in a subcutaneous nodule with acute lymphangitis and regional lymphadenitis, generally with fever. Pneumonia may occur after inhalation or hematogenous dissemination of infection. It may vary in intensity from mild to f ulminant, usually involves the upper lobes, and often results in cavitation. Pleural effusions are uncommon. An acute fulminant septicemia may occur characterized by rapid appearance of hypotension and shock. A chronic suppurative form may involve virtual ly any organ in the body.

Antibiotic regimens that have been used successfully include tetracycline, 2-3 g/day; chloramphenicol, 3 g/day; and trimethoprim-sulfamethoxazole, 4 and 20 mg/kg per day. Ceftazidine and piperacillin have enjoyed success in severely ill patients as wel l. In patients who are toxic, a combination of two antibiotics, given parenterally, is advised.

There are no means of immunization. Vigorous cleansing of abrasions and lacerations may reduce the risk of disease after inoculation of organisms into the skin. There is no information available on the utility of antibiotic prophylaxis after a potenti al exposure before the onset of clinical symptoms.
PRICE: $100,000

Biological Weapons Continued

Q Fever
Q fever is a zoonotic disease caused by a rickettsia, Coxiella burnetii. The most common animal reservoirs are sheep, cattle and goats. Humans acquire the disease by inhalation of particles contaminated with the organisms. A biological warfare attack would cause disease similar to that occurring naturally.

Following an incubation period of 10-20 days, Q fever generally occurs as a self-limiting febrile illness lasting 2 days to 2 weeks. Pneumonia occurs frequently, usually manifested only by an abnormal chest x-ray. A nonproductive cough and pleuritic c hest pain occur in about onefourth of patients with Q fever pneumonia. Patients usually recover uneventfully.

Q fever usually presents as an undifferentiated febrile illness, or a primary atypical pneumonia, which must be differentiated from pneumonia caused by mycoplasma, legionnaire's disease, psittacosis or Chlamydia pneumonia. More rapidly progressi ve forms of pneumonia may look like bacterial pneumonias including tularemia or plague.

Tetracycline (250 mg every 6 hr) or doxycycline (100 mg every 12 hr) for 5-7 days is the treatment of choice. A combination of erythromycin (500 mg every 6 hr) plus rifampin (600 mg per day) is also effective.

Vaccination with a single dose of a killed suspension of C. burnetii provides complete protection against naturally occurring Q fever and >90% protection against experimental aerosol exposure in human volunteers. Protection lasts for at least 5 years. Administration of this vaccine in immune individuals may cause severe cutaneous reactions including necrosis at the inoculation site. Newer vaccines are under development. Treatment with tetracycline during the incubation period will delay but not prevent the onset of illness.
PRICE: $150,000

Ricin
Ricin is a glycoprotein toxin (66,000 daltons) from the seed of the castor plant. It blocks protein synthesis by altering the rRNA, thus killing the cell. Ricin's significance as a potential biological warfare agent relates to its availability world wi de, its ease of production, and extreme pulmonary toxicity when inhaled.

Overall, the clinical picture seen depends on the route of exposure. All reported serious or fatal cases of castor bean ingestion have taken approximately the same course: rapid onset of nausea, vomiting, abdominal cramps and severe diarrhea with vascu lar collapse; death has occurred on the third day or later. Following inhalation, one might expect nonspecific symptoms of weakness, fever, cough, and hypothermia followed by hypotension and cardiovascular collapse. The exact cause of death is unknown an d probably varies with route of intoxication. High doses by inhalation appear to produce severe enough pulmonary damage to cause death.

In oral intoxication, fever, gastrointestinal involvement, and vascular collapse are prominent, the latter differentiating it from infection with enteric pathogens. With regard to inhalation exposure, nonspecific findings of weakness, fever, vomiting, cough, hypothermia, and hypotension in large numbers of patients might suggest several respiratory pathogens.

Therapy is supportive and should include maintenance of intravascular volume. Standard management for poison ingestion should be employed if intoxication is by the oral route. There is presently no antitoxin available for treatment.

There is currently no prophylaxis approved for human use. Active immunization and passive antibody prophylaxis are under study, as both are effective in protecting animals from death following exposure by intravenous or respiratory routes.
PRICE: $200,000

Rift Valley Fever
Rift Valley Fever (RVF) is a viral disease caused by RVF virus. The virus circulates in sub-Saharan Africa as a mosquito-borne agent. Epizootics occur when susceptible domestic animals are infected, and because of the large amount of virus in their ser um, amplify infection to biting arthropods. Deaths and abortions among susceptible species such as cattle and sheep constitute a major economic consequence of these epizootics, as well as providing a diagnostic clue and a method of surveillance. Humans be come infected by the bite of mosquitoes or by exposure to virus-laden aerosols or droplets. The human disease appears to be similar whether acquired by aerosol or by mosquito bite. A biological warfare attack, most likely delivered by aerosol, would be ex pected to elicit the rather specific spectrum of human clinical manifestations and to cause disease in sheep and cattle in the exposed area. If disease occurred in the absence of heavy vector populations or without domestic animals as amplifiers of mosqui to infection, a BW attack would also be a likely cause.

The incubation is two to five days and is usually followed by an incapacitating febrile illness of similar duration. The typical physical findings are fever, conjunctival injection, and sometimes abdominal tenderness. A few petechiae or epistaxis may occur. A small proportion of cases (approximately one percent) will progress to a viral hemorrhagic fever syndrome; mortality in this group is roughly 50 percent. A small number of infections will lead to a late encephalitis. After apparent recovery from a typical febrile illness, the patient develops fever, meningeal signs, obtundation, and focal defects. These patients may die or often have serious sequelae.

The occurrence of an epidemic with febrile disease, hemorrhagic fever, eye lesions, and encephalitis in different patients would be characteristic of RVF. Demonstration of viral antigen in blood by ELISA is rapid and successful in a high proportion of acute cases of uncomplicated disease or hemorrhagic fever.

In hemorrhagic fever, supportive therapy may be indicated for hepatic and renal failure, as well as replacement of coagulation factors. The virus is sensitive to ribavirin in vitro and in rodent models. No studies have been performed in human or the more realistic monkey model to ascertain whether administration to an acutely ill patient would be of benefit.

Avoidance of mosquitoes and contact with fresh blood from dead domestic animals and respiratory protection from small particle aerosols are the mainstays of prevention. An effective inactivated vaccine is available in limited quantities.
PRICE: $150,000

Saxitoxin
Saxitoxin is the parent compound of a family of chemically related neurotoxins. In nature they are predominantly produced by marine dinoflagellates, although they have also been identified in association with such diverse organisms as blue-green algae , crabs, and the blue-ringed octopus. Human intoxications are principally due to ingestion of bivalve molluscs which have accumulated dinoflagellates during filter feeding. The resulting intoxication, known as paralytic shellfish poisoning (PSP), is known throughout the world as a severe, life-threatening illness requiring immediate medical intervention. In a BW scenario, the most likely route of delivery is by inhalation or toxic projectile. In addition, saxitoxin could be used in a confined area to cont aminate water supplies.

After oral exposure, absorption of toxins from the gastrointestinal tract is rapid. Onset of symptoms typically begins 10-60 minutes after exposure, but may be delayed several hours depending upon the dose and individual idiosyncrasy. Initial symptoms are numbness or tingling of the lips, tongue and fingertips, followed by numbness of the neck and extremities and general muscular incoordination. Nausea and vomiting may be present, but typically occur in a minority of cases. Respiratory distress and fl accid muscular paralysis are the terminal stages and can occur 2-12 hours after intoxication. Death results from respiratory paralysis. Clearance of the toxin is rapid and survivors for 12-24 hours will usually recover. There are no known cases of inhalat ion exposure to saxitoxin in the medical literature, but data from animal experiments suggest the entire syndrome is compressed and death may occur in minutes.

Routine laboratory evaluation is not particularly helpful. Cardiac conduction defects may develop. Differential diagnosis may require toxin detection. Diagnosis is confirmed by detection of toxin in the food, water, stomach contents or environmental samples.

Management is supportive and standard management of poison ingestion should be employed if intoxication is by the oral route. Toxins are rapidly cleared and excreted in the urine, so diuresis may increase elimination. Incubation and mechanical respirat ory support may be required in severe intoxication. Timely resuscitation would be imperative, albeit very difficult, after inhalation exposure on the battlefield. No vaccine against saxitoxin exposure has been developed for human use.
PRICE: $100,000

Smallpox
Smallpox virus, an orthopoxvirus with a narrow host range confined to humans, was an important cause of morbidity and mortality in the developing world until recent times. Eradication of the natural disease was completed in 1977 and the last human case s (laboratory infections) occurred in 1978. The virus exists today in only 2 laboratory repositories in the U.S. and Russia. Appearance of human cases outside the laboratory would signal use of the virus as a biological weapon. Under natural conditions, t he virus is transmitted by direct (face-to face) contact with an infected case, by fomites, and occasionally by aerosols. Smallpox virus is highly stable and retains infectivity for long periods outside of the host. A related virus, monkeypox, clinically resembles smallpox and causes sporadic human disease in West and Central Africa.

The incubation period is typically 12 days (range, 10-17 days). The illness begins with a prodrome lasting 2-3 days, with generalized malaise, fever, rigors, headache, and backache. This is followed by defervescence and the appearance of a typical skin eruption characterized by progression over 7-10 days of lesions through successive stages, from macules to papules to vesicles to pustules. The latter finally form crusts and, upon healing, leave depressed depigmented scars. The case fatality rate is app roximately 35% in unvaccinated individuals. Permanent joint deformities and blindness may follow recovery. Vaccine immunity may prevent or modify illness.

The eruption of chickenpox (varicella) is typically centripetal in distribution (worse on trunk than face and extremities) and characterized by crops of lesions in different stages on development. Chickenpox papules are soft and superticial, compared t o the firm, shotty, and deep papules of smallpox. Chickenpox crusts fall off rapidly and usually leave no scar. Monkeypox cannot be easily distinguished from smallpox clinically. Monkeypox occurs only in forested areas of West and Central Africa as a spor adic, zoonotic infection transmitted to humans from wild squirrels. Person-to-person spread is rare and ceases after 1-2 generations. Mortality is 15%. Other diseases that are sometimes confused with smallpox include typhus, secondary syphilis, and malign ant measles. Skin samples (scrapings from papules, vesicular fluid, pus, or scabs) may provide a rapid identification of smallpox by direct electron microscopy, agar gel immunoprecipitation, or immunofluorescence.

There is no specific treatment available although some evidence suggests that vaccinia-immune globulin may be of some value in treatment if given early in the course of the illness.

Vaccinia virus is a live poxvirus vaccine that induces strong crossprotection against smallpox for at least 5 years and partial protection for 10 years or more. The vaccine is administered by dermal scarification or intradermal jet injection; appearan ce of a vesicle or pustule within several days is indication of a "take." Vaccinia-immune human globulin at a dose of 0.3 mg/kg body weight provides >70% protection against naturally occurring smallpox if given during the early in cubation period. Administration immediately after or within the first 24 hours of exposure would provide the highest level of protection, especially in unvaccinated persons. The antiviral drug, n-methylisatin ß-thiosemicarbazone (Marboran®) aff orded protection in some early trials, but not others, possibly because of noncompliance due to unpleasant gastrointestinal side effects.

Patients with smallpox should be treated by vaccinated personnel using universal precautions. Objects in contact with the patient, including bed linens, clothing, ambulance, etc.; require disinfection by fire, steam, or sodium hypochlorite solution.
PRICE: $275,000

Staphylococcal Enterotoxin B. [SEB]
Staphylococcal Enterotoxin B (SEB) is one of several exotoxins produced by Staphylococcus aureus, causing food poisoning when ingested. A BW attack with aerosol delivery of SEB to the respiratory tract produces a distinct syndrome causing signi ficant morbidity and potential mortality.

The disease begins 1-6 hours after exposure with the sudden onset of fever, chills, headache, myalgia, and nonproductive cough. In more severe cases, dyspnea and retrosternal chest pain may also be present. Fever, which may reach 103-106° F, has lasted 2-5 days, but cough may persist 1-4 weeks. In many patients nausea, vomiting, and diarrhea will also occur. In moderately severe laboratory exposures, lost duty time has been <2 weeks, but, based upon animal data, it is anticipated that severe exp osures will result in fatalities.

In foodborne SEB intoxication, fever and respiratory involvement are not seen, and gastrointestinal symptoms are prominent. The nonspecific findings of fever, nonproductive cough, myalgia, and headache occurring in large numbers of patients in an epide mic setting would suggest any of several infectious respiratory pathogens, particularly influenza, adenovirus, or mycoplasma. In a BW attack with SEB, cases would likely have their onset within a single day, while naturally occurring outbreaks would prese nt over a more prolonged interval.

Treatment is limited to supportive care. No specific antitoxin for human use is available. There currently is no prophylaxis for SEB intoxication. Experimental immunization has protected monkeys, but no vaccine is presently available for human use.
PRICE: $100,000

Trichothecene Mycotoxins
The trichothecene mycotoxins are a diverse group of more than 40 compounds produced by fungi. They are potent inhibitors of protein synthesis, impair DNA synthesis, alter cell membrane structure and function, and inhibit mitochondrial respiration. Sec ondary metabolizes of fungi, such as T-2 toxin and others, produce toxic reactions called mycotoxicoses upon inhalation or consumption of contaminated food products by humans or animals. Naturally occurring trichothecenes have been identified in agricultu ral products and have been implicated in a disease of animals known as moldy corn toxicosis or poisoning.

There are no well-documented cases of clinical exposure of humans to trichothecenes. However, strong circumstantial evidence has associated these toxins with alimentary toxic aleukia (ATA), the fatal epidemic seen in Russia during World War II, and wit h alleged BW incidents ("yellow rain") in Cambodia, Laos and Afghanistan.

Consumption of these mycotoxins results in weight loss, vomiting, skin inflammation, bloody diarrhea, diffuse hemorrhage, and possibly death. The onset of illness following acute exposure to T-2 (IV or inhalation) occurs in hours, resulting in the rapi d onset of circulatory shock characterized by reduced cardiac output, arterial hypotension, lactic acidosis and death within 12 hours.

Clinical signs and symptoms of ATA were hemorrhage, leukopenia, ulcerative pharyngitis, and depletion of bone marrow. The purported use of T-2 as a BW agent resulted in an acute exposure via inhalation and/or dermal routes, as well as oral exposure upo n consumption of contaminated food products and water. Alleged victims reported painful skin lesions, lightheadedness, dyspnea, and a rapid onset of hemomhage, incapacitation and death. Survivors developed a radiation-like sickness including fever, nausea , vomiting, diarrhea, leukopenia, bleeding, and sepsis.

Specific diagnostic modalities are limited to reference laboratories. Because of their long "half-life" the toxin metabolizes can be detected as late as 28 days after exposure.

General supportive measures are used to alleviate acute T-2 toxicoses. Prompt (within 5-60 min of exposure) soap and water wash significantly reduces the development of the localized destructive, cutaneous effects of the toxin. After oral exposure mana gement should include standard therapy for poison ingestion.

Ascorbic acid (400-1200 mg/kg, inter-peritoneal (ip)) works to decrease lethality in animal studies, but has not been tested in humans. While not yet available for humans, administration of large doses of monoclinal antibodies directed against T-2 and metabolizes have shown prophylactic and therapeutic efficacy in animal models.
PRICE: $100,000

Tularemia
Tularemia is a zoonotic disease caused by Francisella tularensis, a gram-negative bacillus. Humans acquire the disease under natural conditions through inoculation of skin or mucous membranes with blood or tissue fluids of infected animals, or b ites of infected deerflies, mosquitoes, or ticks. A BW attack with F. tularensis delivered by aerosol would primarily cause typhoidal tularemia, a syndrome expected to have a case fatality rate which may be higher than the 5-10% seen when dise ase is acquired naturally.

A variety of clinical forms of tularemia are seen, depending upon the route of inoculation and virulence of the strain. In humans, as few as 10-50 organisms will cause disease if inhaled or injected intradermally, whereas 108 organisms are r equired with oral challenge. Under natural conditions, ulceroglandular tularemia generally occurs about 3 days after intradermal inoculation (range 2-10 days), and manifests as regional lymphadenopathy, fever, chills, headache, and malaise, with or withou t a cutaneous ulcer. Gastrointestinal tularemia occurs after drinking contaminated ground water, and is characterized by abdominal pain, nausea, vomiting, and diarrhea. Bacteremia probably is common after primary intradermal, respiratory, or gastrointesti nal infection with F. tularensis and may result in septicemia or "typhoidal" tularemia. The typhoidal form also may occur as a primary condition in 5-15% of naturally-occurring cases; clinical features include fever, prostration, and weight loss, but without adenopathy. Diagnosis of primary typhoidal tularemia is difficult, as signs and symptoms are nonspecific and there frequently is no suggestive exposure history. Pneumonic tularemia is a severe atypical pneumonia that may be fulmi nant, and can be primary or secondary. Primary pneumonia may follow direct inhalation of infectious aerosols, or may result from aspiration of organisms in cases of pharyngeal tularemia. Pneumonic tularemia causes fever, headache, malaise, substernal disc omfort, and a non-productive cough; radiologic evidence of pneumonia or mediastinal lymphadenopathy may or may not be present. A biological warfare attack with F. tularensis would most likely be delivered by aerosol, causing primarily typhoidal tu laremia. Many exposed individuals would develop pneumonic tularemia (primary or secondary), but clinical pneumonia may be absent or non-evident. Case fatality rates may be higher than the 5-10% seen when the disease is acquired naturally.

The clinical presentation of tularemia may be severe, yet nonspecific. Differential diagnoses include typhoidal syndromes (e.g., salmonella, rickettsia, malaria) or pneumonic processes (e.g., plague, mycoplasma, SEB). A clue to the diagnosis of tularem ia delivered as a BW agent might be a large number of temporally clustered patients presenting with similar systemic illnesses, a proportion of whom will have a nonproductive pneumonia. Identification of organisms by staining ulcer fluids or sputum is gen erally not helpful. Routine culture is difficult, due to unusual growth requirements and/or overgrowth of commensal bacteria.

Streptomycin (1 gm q 12 intramuscular (IM) for 10-14 days) is the treatment of choice. Gentamicin also is effective (3-5 mg/kg/day parenterally for 10-14 days). Tetracycline and chloramphenicol treatment are effective as well, but are associated with a significant relapse rate. Although laboratory-related infections with this organism are very common, human-to-human spread is unusual and isolation is not required.

A live, attenuated tularemia vaccine is available as an investigational new drug (IND). This vaccine has been administered to more than 5,000 persons without significant adverse reactions and is of proven effectiveness in preventing laboratory-acquire d typhoidal tularemia. Its effectiveness against the concentrated bacterial challenge expected in a BW attack is unproven. The use of antibiotics for prophylaxis against tularemia is controversial.
PRICE: $175,000

Venezuelan Equine Encephalitis
Eight serologically distinct viruses belonging to the Venezuelan equine encephalitis (VEE) complex have been associated with human disease; the most important of these pathogens are designated subtype 1, variants A, B and C. These agents also cause sev ere disease in horses, mules, and donkeys (Equidae). Natural infections are acquired by the bites of a wide variety of mosquitoes; Equidae serve as the viremic hosts and source of mosquito infection. In natural human epidemics, severe and often fatal ence phalitis in Equidae always precedes that in humans. A BW attack with virus disseminated as an aerosol would cause human disease as a primary event. If Equidae were present, disease in these animals would occur simultaneously with human disease. Secondary spread by person-to-person\contact occurs at a negligible rate. However, a BW attack in a region populated by Equidae and appropriate mosquito vectors could initiate an epizootic/epidemic.

Nearly 100% of those infected suffer an overt illness. After an incubation period of 1-5 days, onset of illness is extremely sudden, with generalized malaise, spiking fever, rigors, severe headache, photophobia, myalgia in the legs and lumbosacral area. Nausea, vomiting, cough, sore throat, and diarrhea may follow. This acute phase lasts 24-72 hours. A prolonged period of aesthenia and lethargy may follow, with full health and activity regained only after 1-2 weeks. Approximately 4% of patien ts during natural epidemics develop signs of central nervous system infection, with meningismus, convulsions, coma, and paralysis. These necrologic cases are seen almost exclusively in children. The overall case-fatality rate is <1%, but in childr en with encephalitis, it may reach 20%.

An outbreak of VEE may be difficult to distinguish from influenza on clinical grounds. Clues to the diagnosis are the appearance of a small proportion of neurological cases or disease in Equidae, but these might be absent in a BW attack.

There is no specific therapy. Patients who develop encephalitis may require anticonvulsant and intensive supportive care to maintain fluid and electrolyte balance, adequate ventilation, and to avoid complicating secondary bacterial infections.

An experimental vaccine, designated TC-83 is a live, attenuated cellculture-propagated vaccine which has been used in several thousand persons to prevent laboratory infections. Approximately 10% of vaccinees fail to develop detectable neutralizi ng antibodies, but it is unknown whether they are susceptible to clinical infection if challenged. A second investigational product that has been tested in humans is the C-84 vaccine, prepared by formalin-inactivation of the TC-83 strain. The vaccine is p resently not recommended for primary immunization, on the basis of animal studies indicating that it may not protect against aerosol infection. In experimental animals, alpha-interferon and the interferon-inducer poly-ICLC (lysine-polyadenosine) have proven highly effective for post-exposure prophylaxis of VEE. There are no clinical data on which to assess efficacy in humans.
PRICE: $200,000

Mobile Launching Platforms

Mobile Rail Launcher (MRL)
http://www.globalsecurity.org/wmd/systems/images/rgmx_02.jpg

Price: $300,000


Rye Class Mobile Launcher (RCML)
http://www.globalsecurity.org/wmd/systems/images/image026.jpg

Price: $200,000


Lacour Class Mobile Launcher (LCML)
http://www.globalsecurity.org/wmd/systems/images/us_hml_07_s.jpg

Price: $250,000


Dufour Class Mobile Luancher (DCML)
http://www.globalsecurity.org/wmd/systems/images/hml_03s.jpg

Price: $300,000

[OOC: I may be interested in purchasing later, but there is a problem with your links. Whenever you click on the (presumed) pic link, it redirects you to this thread. Don't know if it's just my computer, but just a helpful reminder.]

Air Munitions

AGM-45 Shrike Missile
http://www.military.com/Data/EQG/agm45_large.jpg

Propulsion: Solid-fuel rocket

Length: 10 feet (3.05 meters)

Weight: 390 pounds (177.06 kilograms)

Diameter: 8 inches (20.32 centimeters)

Wingspan: 3 feet (.914 meters)

Warhead: Conventional

Guidance System: Passive radar homing

Platforms: A-4 Skyhawk, A-6 Intruder

Unit Cost: $32,000


AIM-7 Sparrow
http://www.military.com/Data/EQG/aim7_large.jpg

Propulsion: Hercules MK-58 solid-propellant rocket motor

Length: 12 feet (3.64 meters)

Weight: Approximately 500 pounds (225 kilograms)

Diameter: 8 inches (0.20 meters)

Wingspan: 3 feet, 4 inches (1 meter)

Warhead: Annular blast fragmentation

Guidance System: LSW semiactive on either continuous wave or pulsed Doppler radar energy

Unit Cost: $125,000


AIM-54 Phoenix Missile
http://www.military.com/Data/EQG/aim54phoenix_large.jpg

Propulsion: Hercules MK-58 solid-propellant rocket motor

Length: 13 feet (3.9 meters)

Weight: 1,024 pounds (460.8 kilograms)

Diameter: 15 inches (38.1 centimeters)

Wingspan: 3 feet (.9 meter)

Warhead: Proximity fuse, high explosive

Guidance System: Semi-active and active radar homing

Unit Cost: $477,131


BLU-82 "Daisy Cutter"
http://www.military.com/Data/EQG/blu82_large.jpg

Length: 11.8 feet (3.63 meters)

Weight: 15,000 lbs (6,818 kg.)

Diameter: 4.5 feet (1.38 meters)

Warhead: 12,600 lbs GSX Aluminum-based slurry

Unit Cost: $27,318


CBU-87 Combined Effects Munition (Cluster Bomb)
http://www.military.com/Data/EQG/cbu87_large.jpg

Length: 7.6 feet (2.35 meters)

Weight: 950 lbs. (432 kg.)

Diameter: 15.6 inches

Warhead: 202 x BLU-97/B CEB

Unit Cost: $13,941


Penguin Anti-Ship Missile
http://www.military.com/Data/EQG/penguin_large.jpg

Propulsion: Solid propellant rocket motor and solid propellant booster

Length: 120.48 inches (3.06 meters)

Weight: 847 pounds (385 kilograms)

Diameter: 11.2 inches (28.45 centimeters)

Wingspan: 39 inches (71.12 centimeters)

Warhead: 265 pounds (120.5 kilograms), semi armor piercing

Guidance System: Inertial and infrared terminal

Unit Cost: $70,000


Tomahawk Cruise Missile
http://www.military.com/Data/EQG/tomahawk_large.jpg

Propulsion: LSW F107-WR-402 cruise turbo-fan engine; CSD/ARC solid-fuel booster

Length: 18 feet 3 inches (5.56 meters)

Weight: 2,900 pounds (1,315.44 kilograms)

Diameter: 20.4 inches (51.81 centimeters)

Wingspan: 8 feet 9 inches (2.67 meters)

Warhead: 1,000 pounds or conventional submunitions dispenser with combined effect bomblets

Guidance System: TERCOM, DSMAC, and GPS (Block III only)

Unit Cost: $500,000


AGM-88 HARM
http://www.military.com/Data/EQG/agm88_large.jpg

Propulsion: Thiokol dual-thrust rocket motor

Length: 13 feet, 8 inches (4.14 meters)

Weight: 800 pounds (360 kilograms)

Diameter: 10 inches (25.40 centimeters)

Wingspan: 3 feet, 8 inches (101.60 centimeters)

Warhead: High explosive

Guidance System: Proportional

Platforms: Used aboard the F-16C

Unit Cost: $200,000


AIM-9 Sidewinder
http://www.military.com/Data/EQG/aim9_large.jpg

Propulsion: Hercules and Bermite Mk 36 Mod 11

Length: 9 feet, 5 inches (2.87 meters)

Weight: 190 pounds (85.5 kilograms)

Diameter: 5 inches (0.13 meters)

Wingspan: 2 feet, 3/4 inches (0.63 meters)

Warhead: Annular blast fragmentation

Guidance System: Solid-state, infrared homing system

Unit Cost: $84,000


AIM-120 AMRAAM
http://www.military.com/Data/EQG/aim1120_large.jpg

Propulsion: High performance

Length: 143.9 inches (366 centimeters)

Weight: 335 pounds (150.75 kilograms)

Diameter: 7 inches (17.78 centimeters)

Wingspan: 20.7 inches (52.58 centimeters)

Warhead: Blast fragmentation

Guidance System: Active radar terminal/inertial midcourse

Unit Cost: $386,000


CBU-89 Gator Air-Delivered Mines
http://www.military.com/Data/EQG/cbu89_large.jpg

Length: 7.67 feet (2.36 meters)

Weight: 710 lb (322 kg)

Diameter: 16 inches

Warhead: 72 x BLU-91/B AT mines OR 22 x BLU-92/B AP mines

Unit Cost: $39,963


Guided Bomb Unit-15
http://www.military.com/Data/EQG/gbu15_large.jpg

Propulsion: Solid-fuel rocket

Length: 11 feet (3.3 meters)

Weight: 2,500 pounds (1,125 kilograms)

Diameter: 2,500 pounds (1,125 kilograms)

Wingspan: 4 feet, 11 inches (1.49 meters)

Warhead: MK-84 general purpose or BLU-109 penetrating bombs

Guidance System: Television or imaging infrared seeker via data link

Unit Cost: $245,000


SLAM ER Missile Systems
http://www.military.com/Data/EQG/slam-er_large.jpg

Propulsion: Teledyne Turbojet and solid propellant booster for surface and submarine launch

Length: 14 feet 4 inches (4.36 meters)

Weight: 1,400 pounds (635.04 kilograms)

Diameter: 13.5 inches (34.29 centimeters)

Wingspan: 7.158 feet (2.1819 meters)

Guidance System: Ring laser gyro Inertial Navigation System (INS) with multi-channel GPS

Unit Cost: $500,000

Air Defense

Avenger Weapons System
http://www.military.com/Data/EQG/avenger_large.jpg

Length: 182 inches (4.62 meters)

Height: 104 inches (2.64 meters)

Width: 87 inches (2.21 meters)

Weight:
Unloaded: 2,025 pounds (919.35 kilograms)

Loaded: 2,568 pounds (1,165.87 kilograms)

Sight Ring: 360 degrees

Caliber: 50 caliber

Rate of Missile Fire: One missile every three to seven seconds

Range: 4.35 miles (seven kilometers)

Stinger Missile Fuzing: Penetration, Impact, Self destruct

Initial Load: Eight missiles; can be reloaded

Unit Cost: $617,000


Patriot Missile
http://www.military.com/Data/EQG/Patriot-mainpic_medium.jpg

Length: 20 feet

Diameter: 1.33 feet

Weight: 2003 pounds

Propulsion solid propellant

Guidance: command guidance and track via missile

Speed: Supersonic

Warhead: Proximity fuzed high explosive in a high-fragmentation casing

Unit Cost: $887,000


Sea Sparrow Missile
http://www.military.com/Data/EQG/seasparrow_large.jpg

Length: 12 feet (3.64 meters)

Diameter: 8 inches (20.3 cm)

Weight: Approximately 500 pounds (225 kilograms)

Propulsion Hercules MK-58 solid-propellant rocket motor

Guidance: Raytheon semi-active on continuous wave or pulsed Doppler radar energy

Speed: More than 2,660 mph (4,256 kph)

Warhead: Annular blast fragmentation warhead, 90 pounds (40.5 kilograms)

Unit Cost: $165,400


Stinger Weapons System: RMP & Basic
http://www.military.com/Data/EQG/stinger_large.jpg

Length: 9.2 feet (2.80 meters)

Diameter: 3.6 inches (9.14 cm)

Weight: Fully Armed: 34.5 pounds (15.66 kilograms)

Propulsion Dual thrust solid fuel rocket motor

Guidance: Fire-and-forget passive infrared seeker

Speed: Supersonic in flight

Warhead: High explosive

Unit Cost: $38,000


Hawk Surface-to-Air Missile System
http://www.military.com/Data/EQG/hawk_large.jpg

Length: 12.5 feet (3.81 meters)

Diameter: 13.5 inches (3.84 centimeters)

Weight: Fully armed: 1,400 pounds (635 kilograms)

Propulsion Solid propellant rocket motor

Guidance: Radar directed semi-active homing

Speed: Supersonic

Warhead: One 300 pound (136.2 kilogram) high explosive missile

Unit Cost: $2,500,000


RIM-116A Rolling Airframe Missile (RAM)
http://www.military.com/Data/EQG/rim116_large.jpg

Length: 9.2 feet (2.80 meters)

Diameter: 5 inches (12.70 centimeters)

Weight: 162 pounds (73.48 kilograms)

Propulsion Solid propellant rocket motor

Speed: Supersonic

Warhead: 25 pounds (22.68 kilograms), conventional

Unit Cost: $325,000


Standard Missile
http://www.military.com/Data/EQG/standard_large.jpg

Length: 14 feet, 7 inches (4.41 meters)

Diameter: 13.5 inches (34.3 cm)

Weight: 1,380 pounds (621 kilograms)

Propulsion Dual thrust, solid fuel rocket

Speed: Subsonic

Warhead: Proximity fuse, high explosive

Unit Cost: $252,500

The Louisiana Strategic Works new storefront is officially open. The first 10 orders will recieve a 30% discount.

We will also happily sign contracts with nations. This would give your nation a 35% discount that continues as long as the contract is valid. Discounts for normal purchases can not be added on to contract discounts.

bump! First customer will recieve a 50% discount!

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The Federative Commonwealth of Armany would like to procure ten (10) LGM-118A Peacekeeper ICBM's and twenty (20) Patriot missiles for the grand total of $358.87 million dollars, with the 50% first customer discount included. We hope that LSW sees it fit to deliver the weapons to us and look forward to future dealings with Louisiana Strategic Works.

Signed:
Larry Mitchell
Arman Secretary of Defense

Armany, your order is confirmed.

Come on people, you know you all want to be nuclear powers. At lease those of you who arent already.

Seeing that we have had a successful initial order with LSW, the Defense Department has found it to be beneficial that we pursue a contract with LSW to fufill our various strategic needs. What are the host companiy's terms for such a contract? If these terms are found suitable, which, considering Lousiana Strategic Works' previous dealings, is highly probable, then the government of Armany would be more than willing to sign a contract with the company.

Also, in reference to our previously acquired ICBM's, is it neccessary to procure our own nuclear materials to fit in these weapons, or are they already included?

-Larry Mitchell
Arman SecDef

TO: Armany Defense Department
FROM: Louisiana Strategic Works

SUBJECT: Possible Contract Agreements

We can have contract made to build anything on our storefront and even special orders if given enough information. Normally our contract times are 5 years, 10 years, 15 years, and 20 years. Prices of contract do vary depending on what you are interested in contracting us to produce. We are currently starting to invest in satillite technology and we will soon be able to produce, launch, and help operate different military, communications, GPS, and etc. satillites. Also being worked on is highly advanced Mobile radars that locates hostile artillery and mortar fire with first-round accuracy that can also be used to register friendly fire.

Anyways, to have a set price, we will have to first know what you are interested in purchasing.

To: Louisiana Strategic Works
From: Armany Dept. of Defense
Re: Possible Contract

In response to your question, we would be interested in purchasing ordnance for our expected air force (i.e. AIM-120's, etc.) as well as more defensive missile systems and also some offensive missiles (ICBM's, possibly SLBM's). To do this, we know that our budget would be stretched slightly, so we are interested in setting up a contract to receive a constant flow of arms with a bit of a discount. We would want a good number of aerial-based weapons, as well as a smaller amount of the nuclear missiles and the defensive (Patriot) missile systems. It would be desired that the contract would not be too excessive, as our military budget, in accordance with our nation population, is circa $433,000,000,000 give or take several hundred million dollars. Assuming a spending allowance of 4% on weapons purchases for all three branches of our military (excluding major equipment, such as ships, planes), we would be willing to spend an amount of several billion at a maximum on a contract with LSW, with the possibility of other dealings in the future consisting of more money. We may also be interested in procuring some of your satellite technology in the future, after further review.

If you could present any options dealing with contracts as far as our desired spending limits are concerned, then please do so.

-Howard Sommers
Federal Accounting Office (FAO)

-Larry Mitchell
Defense Dept.

In accordance with the wishes of President William R. Nash and the Congressional Defense Committee.

BuMp

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The Peoples' Republic of Revionia is interested in conducting its own biological and chemical weapons testing, so we would wish to buy the following.

100 pounds of every Chemical agent, 93,000 dollars.

500 pounds of every Biological agent, 25,500,000 dollars.

Revionia was also interested in purchasing 100 Penguin Anti-Ship Missiles and Hawk Surface-to-Air Missile Systems.

A total that comes down to 310,593,000 dollars. Wired when comfirmed.

You'll be hearing from us again if all goes well.

By the way; Revionia was also interested if Louisiana could give some advice where we might obtain specimen of the Hepatitis B Virus, we have seen new possiblities with it....

Revionia, we thank you for your order and it is confirmed and will be placed on the first Cimarron Class Cargo Ship leaving Bridge City.

We currently do not have a specimen of the Hepatitis B Virus but we could easily get one for you within a couple of days. We will have to extract our mother speciman from our CDC bank.

We will be recieveing a telegram within the next days on the Hepatitis B Virus.

Thank you very much,



President Bobby Jindal
President of Louisiana Strategic Works
Chemical and Biological Division
Bridge City, Texas, Communist Louisiana

We would like to buy only a small amount of nuclear weapons to start with and then we may come back for more if we are interested in purchasing more.

SS-8
quantity: 6
cost: $80000000
total:$480000000

Thank you

tag

USTIO, your order will be confirmed as soon as I recieve a telegram that you have agreed to the treaty. Until then, the ships will sit about 50 nm out from your nations coast.

Also, if this treaty is signed, you will only have to pay 1/4 of the total cost and the rest will be covered by the treaty agreement.

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Space Union's military would like to order the following:

5,714 LGM-118A Peacekeepers
2,222 Atlas D
1250 SS-8
15,000 LGM-30 Minuteman III

Total Cost: $1 trillion

Money will be wired upon confirmation.

Also I would like to ask when my order will be complete?

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The People's Republic of Revionia wishes to make more purchases; but stresses that the shipment must come soon, since Revionia is facing a possible full naval blockage and military encirlement. Revionia wishes to arm itself with nuclear warheads as a deterrent of the agressing imperialist nations.

6 LGM-30 Minuteman II ICBMs 120,000,000

20 Lacour Class Mobile Launchers 5,000,000




A total of 125,000,000 dollars will be wired when confirmed.

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Revonia:

He won't sell you nuclear weapons because you under 2 months old.

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There, just change my order to ICBMs that aren't armed with nuclear warheads...

Space Union, your request is confirmed.

Revionia, I can not sell nuclear items to nations your size. Also, I refuse to sell the ICBM's.

The Empire of Cotland would like to purchase 300 LGM-118A Peacekeeper ICBMs. The total cost of 210 billion USD will be wired upon confirmation of the order.

Cotland, your order is confirmed.

public anouncement of inquiry into your systems.

My nation is small, new, and represents a unique challenge for your company, and an opertunity. I would like to open a discussion with you about the opertunitys in growth that we might both explore.

[OOC: I've saved up and made my decision; I am going nuclear, on a samll level.]

The Novikovian People's Military (NPM) is currently looking to develop a strategic missile force capable for deterring nuclear-capable nations within a 12,000 km distance of the Novikovian heartland. We wish to emphasize that we have, thus far, been unable to deter foreign aggressors and maintain the sanctity of Novikov’s soil. Following the path of other recent military reforms, we are seeking to expand out missile regiments with the introduction of the LGM-30 and R-9B SS-8 Intercontinental Ballistic Missiles to equip five newly formed missile batteries. Our request, therefore, consists of:

72 LGM-30 Minuteman III ICBMs (1,440,000,000 USD)
18 R-9B SS-8 Sasin ICBMs (1,440,000,000 USD)

Additionally, we wish to jump-start our biological weapons program – discontinued twelve years ago – with the deployment of new biological weapons, possibly obtained abroad. If possible, we would like to then extend our order to include:

100 Units of Congo-Crimean Hemorrhagic Fever (15,000,000 USD)
25 Units of Ricin (5,000,000 USD)

The total price for these units comes to 2,900,000,000 USD. These funds can be transferred immediately to Communist Louisiana’s government, or be held until completion of this order. We request that, if at all possible, at least one dozen LGM-30 and one half dozen SS-8 units be shipped within the next three months, in addition to any biological weapons which can be obtained within that time period – shipping can be undertaken by Novikov’s Merchant Marine if needed. We apologize for any inconvenience this request may constitute, and look forward to further dealings with Communist Louisiana.

-[signed] NPM Strategic Weapons Command

TO: NPM Strategic Weapons Command
FROM: LSW

SUBJECT: WEAPONS PURCHASE

We will confirm your nations orders and its request to have the weapons. We will handle the shipping of the cargo. We do this because included with the price is not only shipping charges, but insurance and to have the insurance, they must be shipped by special built ships.

The people of Communist Louisiana have the sincere thanks of the Novikovian Government for all they have done to further the defense of Novikov and her people. Your funds will be transfered as sson as the first missile is installed on-site at the 1st Battery silos inside Novikov - estimated four months from today. Again, we extend the thanks of Novikov and its people.

-[signed] NPM Strategic Weapons Command

Stonedeep, please telegram me or use one of my messengers to get ahold of me and tell me your ideas.

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The Neuvo Rican biological warfare wing, has recently undergone expansion and would like to purchase:

40 lots of anthrax for $10 million

Thank you.

Neuvo Rica, your order is confirmed.

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the tokera is interested in what satelite technology you have/ are developing, and do you have any space based missle launch platforms.

At this time we dont have many spaced based weapons systems. Some of our ICBM's though (Peacekeepers) do preform a majority of there actions in space. Meaning once the rocket enters earths orbit, a majority of the rocket blows off leaving only the warheads. These warheads which would be nearly impossible to destroy once entering the eaths atmosphere could be targeted at some many different targets at one time.

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BuMp.

Next 5 orders will recieve 15% discounts!